About Gene List

PF3D7_0526000

Genome location: Pf3D7_05_v3:1,075,782..1,079,027(-)

Genome classification: Core

Function and Localization

Product Description: RAP protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite expressed 0.30 0.81
Schizont expressed 0.07 0.95
Gametocyte expressed 0.41 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0526000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.143 | MFS: -2.945 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1240800)

  • Relative Growth Rate: 0.11 ± 0.07
  • Confidence: 6.64

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3K5

"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=0.19) with 6H4M (Global RMSD=13.25)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532791

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 32 17 37
disruptive 61 126 46 131
missense 36 92 41 110

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 12 63 26 51
disruptive 92 212 94 191
missense 51 162 64 124

PlasmoDB Total SNPs: 262

Non-coding: 131 | Synonymous: 55 | Nonsynonymous: 71 | Stop Codon: 5

Protein Information

Protein Length: 806 | Molecular Weight (kDa): 98.499

UniProt ID(s): Q8I3K5

PDB ID(s): None

Isoelectric Point: 9.76

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013584 RAP domain
PFam PF08373 RAP domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095