Product Description: RAP protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | not expressed | 0.06 | 0.97 |
Trophozoite | expressed | 0.30 | 0.81 |
Schizont | expressed | 0.07 | 0.95 |
Gametocyte | expressed | 0.41 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0526000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.143 | MFS: -2.945 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1240800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3K5
"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=0.19) with 6H4M (Global RMSD=13.25)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 6 | 32 | 17 | 37 |
disruptive | 61 | 126 | 46 | 131 |
missense | 36 | 92 | 41 | 110 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 12 | 63 | 26 | 51 |
disruptive | 92 | 212 | 94 | 191 |
missense | 51 | 162 | 64 | 124 |
PlasmoDB Total SNPs: 262
Non-coding: 131 | Synonymous: 55 | Nonsynonymous: 71 | Stop Codon: 5
Protein Length: 806 | Molecular Weight (kDa): 98.499
UniProt ID(s): Q8I3K5
PDB ID(s): None
Isoelectric Point: 9.76
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR013584 | RAP domain |
PFam | PF08373 | RAP domain |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |