PF3D7_0526100

Genome location: Pf3D7_05_v3:1,079,225..1,081,313(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	not expressed	0.39	0.76
Schizont	not expressed	0.08	0.95
Gametocyte	expressed	0.60	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0526100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.148 | MFS: -2.96 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3K4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532533

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	25	7	26
disruptive	7	43	32	56
missense	6	39	29	53

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	39	13	25
disruptive	22	103	55	71
missense	12	85	48	57

PlasmoDB Total SNPs: 96

Non-coding: 54 | Synonymous: 29 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 409 | Molecular Weight (kDa): 49.601

UniProt ID(s): Q8I3K4

PDB ID(s): None

Isoelectric Point: 9.38

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A