Genome location: Pf3D7_05_v3:1,081,123..1,084,702(-)
Genome classification: Core
Product Description: ADP-ribosylation factor GTPase-activating protein 2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0005096 | GTPase activator activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | nd | nd |
| Trophozoite | expressed | nd | nd |
| Schizont | expressed | nd | nd |
| Gametocyte | expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0526200.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.993 | MFS: -1.737 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1241000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1241000)
Modification: Disrupted | RMgm-3371
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZVA6
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=0.32) with 3LVQ (Global RMSD=4.92)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100831
Most Similar Human Ortholog: X6RCC3
TM-align score: 0.59 | RMSD: 2.71
Seq Identity: 0.37 | Length: 118 / 506
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000084070 | small ArfGAP2 |
| ENSG00000112305 | small ArfGAP 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 29 | 12 | 25 |
| disruptive | 15 | 63 | 44 | 101 |
| missense | 10 | 59 | 42 | 88 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 62 | 17 | 25 |
| disruptive | 31 | 151 | 56 | 146 |
| missense | 22 | 129 | 46 | 105 |
PlasmoDB Total SNPs: 249
Non-coding: 203 | Synonymous: 25 | Nonsynonymous: 21 | Stop Codon: 0
Protein Length: 506 | Molecular Weight (kDa): 58.599
UniProt ID(s): C0H4G3
PDB ID(s): None
Isoelectric Point: 8.63
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001164 | Arf GTPase activating protein |
| InterPro | IPR037278 | ARFGAP/RecO-like zinc finger |
| PFam | PF01412 | Arf GTPase activating protein |
| Superfamily | SSF57863 | ARFGAP/RecO-like zinc finger |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 31331965 | Dissection of GTPase-activating proteins reveals functional asymmetry in the COPIcoat of budding yeast | Arakel EC, Huranova M, ..., Schwappach B | 10.1242/jcs.232124 |