Genome location: Pf3D7_05_v3:1,085,623..1,087,455(-)
Genome classification: Core
Product Description: WD repeat-containing protein 55, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005730 | nucleolus |
Process | GO:0006364 | rRNA processing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.19 | 0.90 |
Trophozoite | expressed | 0.14 | 0.91 |
Schizont | expressed | 0.08 | 0.94 |
Gametocyte | expressed | 0.17 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0526300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.169 | MFS: -2.932 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3K2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102834
Most Similar Human Ortholog: Q9H6Y2
TM-align score: 0.86 | RMSD: 2.17
Seq Identity: 0.23 | Length: 299 / 323
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000120314 | WD repeat domain 55 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 3 | 12 | 8 | 15 |
disruptive | 2 | 27 | 17 | 50 |
missense | 2 | 26 | 15 | 46 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 8 | 20 | 12 | 22 |
disruptive | 11 | 72 | 30 | 75 |
missense | 5 | 60 | 29 | 57 |
PlasmoDB Total SNPs: 121
Non-coding: 93 | Synonymous: 17 | Nonsynonymous: 10 | Stop Codon: 1
Protein Length: 323 | Molecular Weight (kDa): 36.954
UniProt ID(s): Q8I3K2
PDB ID(s): None
Isoelectric Point: 8.82
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR001680 | WD40 repeat |
InterPro | IPR024977 | Anaphase-promoting complex subunit 4, WD40 domain |
InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
PFam | PF12894 | Anaphase-promoting complex subunit 4, WD40 domain |
Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |