About Gene List

PF3D7_0526300 (WDR55)

Genome location: Pf3D7_05_v3:1,085,623..1,087,455(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein 55, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005730 nucleolus
Process GO:0006364 rRNA processing

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.19 0.90
Trophozoite expressed 0.14 0.91
Schizont expressed 0.08 0.94
Gametocyte expressed 0.17 0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0526300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.169 | MFS: -2.932 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3K2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102834

Most Similar Human Ortholog: Q9H6Y2

TM-align score: 0.86 | RMSD: 2.17

Seq Identity: 0.23 | Length: 299 / 323

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000120314 WD repeat domain 55

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 12 8 15
disruptive 2 27 17 50
missense 2 26 15 46

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 20 12 22
disruptive 11 72 30 75
missense 5 60 29 57

PlasmoDB Total SNPs: 121

Non-coding: 93 | Synonymous: 17 | Nonsynonymous: 10 | Stop Codon: 1

Protein Information

Protein Length: 323 | Molecular Weight (kDa): 36.954

UniProt ID(s): Q8I3K2

PDB ID(s): None

Isoelectric Point: 8.82

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001680 WD40 repeat
InterPro IPR024977 Anaphase-promoting complex subunit 4, WD40 domain
InterPro IPR036322 WD40-repeat-containing domain superfamily
PFam PF12894 Anaphase-promoting complex subunit 4, WD40 domain
Superfamily SSF50978 WD40-repeat-containing domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095