PF3D7_0526400

Genome location: Pf3D7_05_v3:1,087,761..1,089,508(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.05	0.96
Schizont	possibly expressed	0.07	0.94
Gametocyte	not expressed	0.08	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0526400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.13 | MFS: -3.135 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1241200)

Relative Growth Rate: 0.97 ± 0.10
Confidence: 5.97

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1241200)

Modification: Disrupted | RMgm-3372

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3K1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171452

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	18	9	23
disruptive	2	16	18	29
missense	2	16	18	29

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	37	13	12
disruptive	2	45	30	66
missense	2	41	28	51

PlasmoDB Total SNPs: 157

Non-coding: 124 | Synonymous: 27 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 361 | Molecular Weight (kDa): 42.363

UniProt ID(s): Q8I3K1

PDB ID(s): None

Isoelectric Point: 8.89

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A