PF3D7_0526500

Genome location: Pf3D7_05_v3:1,090,492..1,095,184(+)

Genome classification: Core

Function and Localization

Product Description: Suf domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0003729	mRNA binding
Process	GO:0031123	RNA 3'-end processing

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.10	0.53
Trophozoite	expressed	0.96	0.50
Schizont	expressed	0.28	0.84
Gametocyte	expressed	0.67	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0526500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.014 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3K0

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=8.95) with 6JWQ (Global RMSD=17.83)

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
P0C6X4	Replicase polyprotein 1ab		OrthoMCL BLAST	cmdc.202100576, 6bUS9975885, Compound 6US9975885, Compound 13US9975885, Compound 14...

Orthology Information

Ortholog Group (OrthoMCL): OG6_162971

No human ortholog(s)

Protein Information

Protein Length: 1384 | Molecular Weight (kDa): 165.382

UniProt ID(s): Q8I3K0

PDB ID(s): None

Isoelectric Point: 7.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003107	HAT (Half-A-TPR) repeat
InterPro	IPR008847	Suppressor of forked
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
PFam	PF05843	Suppressor of forked
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	74	26	77
disruptive	48	122	82	178
missense	33	101	70	157

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	119	51	83
disruptive	80	270	134	253
missense	52	215	116	197

PlasmoDB Total SNPs: 208

Non-coding: 46 | Synonymous: 73 | Nonsynonymous: 89 | Stop Codon: 0

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104