About Gene List

PF3D7_0526600

Genome location: Pf3D7_05_v3:1,098,833..1,116,194(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.11 0.95
Trophozoite not expressed 0.68 0.65
Schizont not expressed 0.36 0.80
Gametocyte not expressed 0.89 0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0526600

Resistome Missense Mutations: P1985T

Resistome Compounds with Missense Mutations: MMV665928

Resistome # Samples with Disruptive Mutations: 2 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.03 | #Insertions: 10

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110153

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 31 100 72 143
disruptive 316 473 191 523
missense 167 295 138 398

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 48 201 108 168
disruptive 450 786 311 695
missense 229 513 238 446

PlasmoDB Total SNPs: 1529

Non-coding: 299 | Synonymous: 679 | Nonsynonymous: 551 | Stop Codon: 0

Protein Information

Protein Length: 4524 | Molecular Weight (kDa): 525.293

UniProt ID(s): Q8I3J9

PDB ID(s): None

Isoelectric Point: 4.85

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011004 Trimeric LpxA-like superfamily
PFam N/A N/A
Superfamily SSF51161 Trimeric LpxA-like superfamily

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104