About Gene List

PF3D7_0526700

Genome location: Pf3D7_05_v3:1,117,087..1,119,867(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.11 0.94
Trophozoite expressed 0.73 0.60
Schizont expressed 0.22 0.87
Gametocyte expressed 0.43 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0526700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.793 | MFS: -1.917 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3J8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_115141

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 36 20 31
disruptive 54 130 70 142
missense 35 92 60 106

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 59 21 42
disruptive 106 254 89 233
missense 59 191 61 145

PlasmoDB Total SNPs: 160

Non-coding: 36 | Synonymous: 69 | Nonsynonymous: 55 | Stop Codon: 0

Protein Information

Protein Length: 796 | Molecular Weight (kDa): 93.605

UniProt ID(s): Q8I3J8

PDB ID(s): None

Isoelectric Point: 5.08

Protein Domain Annotations:

Source Family ID Description
InterPro IPR008479 Protein of unknown function DUF760
PFam PF05542 Protein of unknown function DUF760
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895