About Gene List

PF3D7_0526800

Genome location: Pf3D7_05_v3:1,120,104..1,122,685(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016592 mediator complex
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.51 0.76
Trophozoite expressed 0.82 0.55
Schizont expressed 0.15 0.90
Gametocyte expressed 0.49 0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0526800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.652 | MFS: -2.449 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3J7

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=0.93) with 4EPM (Global RMSD=17.66)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532369

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 13 4 26
disruptive 15 39 31 70
missense 11 30 23 57

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 25 9 35
disruptive 26 98 47 121
missense 20 67 38 78

PlasmoDB Total SNPs: 130

Non-coding: 88 | Synonymous: 15 | Nonsynonymous: 27 | Stop Codon: 0

Protein Information

Protein Length: 368 | Molecular Weight (kDa): 43.782

UniProt ID(s): Q8I3J7

PDB ID(s): None

Isoelectric Point: 7.68

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
28288121 A genetic system to study Plasmodium falciparum protein function. Birnbaum J, Flemming S, ..., Spielmann T 10.1038/nmeth.4223
35557691 Mediator Complex of the Malaria Parasite Plasmodium falciparum Associates withEvolutionarily Novel Subunits. Iyer UB, Park JE, ..., Featherstone M 10.1021/acsomega.2c00368