Product Description: transmembrane emp24 domain-containing protein, putative
SignalP Peptide: MMKIIKEVRAVVLLLFVLLLNSSNVKA
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.10 | 0.95 |
| Trophozoite | possibly expressed | 0.13 | 0.91 |
| Schizont | possibly expressed | 0.04 | 0.97 |
| Gametocyte | possibly expressed | 0.08 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0526900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.264 | MFS: -2.709 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1241700)
Modification: Disrupted | RMgm-4961
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K8K6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102210
Most Similar Human Ortholog: Q7Z7H5
TM-align score: 0.51 | RMSD: 5.20
Seq Identity: 0.18 | Length: 170 / 214
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000158604 | transmembrane p24 trafficking protein 4 |
| ENSG00000184840 | transmembrane p24 trafficking protein 9 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 11 | 7 | 22 |
| disruptive | 4 | 18 | 6 | 25 |
| missense | 4 | 18 | 6 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 27 | 10 | 14 |
| disruptive | 7 | 35 | 21 | 44 |
| missense | 7 | 32 | 18 | 27 |
PlasmoDB Total SNPs: 194
Non-coding: 191 | Synonymous: 1 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 214 | Molecular Weight (kDa): 24.561
UniProt ID(s): A0A5K1K8K6
PDB ID(s): None
Isoelectric Point: 9.75
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009038 | GOLD domain |
| InterPro | IPR015720 | TMP21-related |
| PFam | PF01105 | GOLD domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 33515807 | Systematic Identification of Plasmodium Falciparum Sporozoite Membrane ProteinInteractions Reveals an Essential Role for the p24 Complex in Host Infection. | Knockel J, Dundas K, ..., Wright GJ | 10.1074/mcp.RA120.002432 |