PF3D7_0527400

Genome location: Pf3D7_05_v3:1,138,602..1,141,621(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.25	0.87
Trophozoite	expressed	0.13	0.92
Schizont	expressed	0.07	0.95
Gametocyte	not expressed	0.26	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0527400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.567 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1242200)

Modification: Disrupted | RMgm-3377

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3J1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532834

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	14	5	12
disruptive	10	32	19	33
missense	8	31	19	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	26	5	15
disruptive	16	61	33	40
missense	12	57	26	30

PlasmoDB Total SNPs: 216

Non-coding: 194 | Synonymous: 10 | Nonsynonymous: 11 | Stop Codon: 1

Protein Information

Protein Length: 175 | Molecular Weight (kDa): 20.808

UniProt ID(s): Q8I3J1

PDB ID(s): None

Isoelectric Point: 4.46

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A