Genome location: Pf3D7_05_v3:1,142,668..1,145,603(+)
Genome classification: Core
Product Description: Hsc70-interacting protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0031072 | heat shock protein binding |
| Process | GO:0051085 | chaperone cofactor-dependent protein refolding |
| Process | GO:0061077 | chaperone-mediated protein folding |
| Process | GO:0065003 | protein-containing complex assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.38 | 0.42 |
| Trophozoite | expressed | 1.79 | 0.25 |
| Schizont | expressed | 0.36 | 0.78 |
| Gametocyte | expressed | 1.17 | 0.43 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0527500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.784 | MFS: -2.619 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3J0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104991
Most Similar Human Ortholog: F8WAQ7
TM-align score: 0.87 | RMSD: 0.73
Seq Identity: 0.34 | Length: 38 / 458
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000100380 | ST13 Hsp70 interacting protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 30 | 36 | 21 | 35 |
| disruptive | 54 | 114 | 56 | 87 |
| missense | 16 | 42 | 20 | 48 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 39 | 70 | 14 | 34 |
| disruptive | 85 | 181 | 76 | 114 |
| missense | 23 | 84 | 41 | 65 |
PlasmoDB Total SNPs: 183
Non-coding: 97 | Synonymous: 54 | Nonsynonymous: 32 | Stop Codon: 0
Protein Length: 458 | Molecular Weight (kDa): 51.126
UniProt ID(s): Q8I3J0
PDB ID(s): None
Isoelectric Point: 4.38
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006636 | Heat shock chaperonin-binding |
| InterPro | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| InterPro | IPR019734 | Tetratricopeptide repeat |
| InterPro | IPR034649 | Hsp70-interacting protein, N-terminal |
| InterPro | IPR041243 | STI1 domain |
| PFam | PF17830 | STI1 domain |
| PFam | PF18253 | Hsp70-interacting protein, N-terminal |
| Superfamily | SSF48452 | Tetratricopeptide-like helical domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 16884692 | 15-Deoxyspergualin modulates Plasmodium falciparum heat shock protein function. | Ramya TN, Surolia N, Surolia A | 10.1016/j.bbrc.2006.07.082 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |