PF3D7_0527600

Genome location: Pf3D7_05_v3:1,145,803..1,149,684(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.11	0.94
Trophozoite	expressed	0.42	0.74
Schizont	expressed	0.43	0.72
Gametocyte	expressed	0.98	0.53

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0527600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.634 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1242400)

Relative Growth Rate: 0.90 ± 0.19
Confidence: 4.66

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1242400)

Modification: Disrupted | RMgm-3378

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4G4

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.86) with 3I5X (Global RMSD=24.61)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532593

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	26	12	31
disruptive	14	65	25	80
missense	14	65	25	74

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	47	24	32
disruptive	17	126	56	125
missense	17	114	49	93

PlasmoDB Total SNPs: 276

Non-coding: 235 | Synonymous: 24 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 455 | Molecular Weight (kDa): 52.971

UniProt ID(s): C0H4G4

PDB ID(s): None

Isoelectric Point: 8.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108