Genome location: Pf3D7_05_v3:1,156,067..1,156,986(-)
Genome classification: Core
Product Description: proteasome maturation factor UMP1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Process | GO:0043248 | proteasome assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.21 | 0.89 |
| Trophozoite | expressed | 0.58 | 0.66 |
| Schizont | expressed | 0.32 | 0.79 |
| Gametocyte | expressed | 0.97 | 0.49 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0528000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.146 | MFS: -3.188 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K941
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102572
Most Similar Human Ortholog: A0A1W2PS02
TM-align score: 0.32 | RMSD: 4.63
Seq Identity: 0.10 | Length: 50 / 124
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000132963 | proteasome maturation protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 2 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 40
Non-coding: 33 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 124 | Molecular Weight (kDa): 14.603
UniProt ID(s): A0A5K1K941
PDB ID(s): None
Isoelectric Point: 5.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008012 | Proteasome maturation factor Ump1 |
| PFam | PF05348 | Proteasome maturation factor Ump1 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 26483010 | Identification of Saccharomyces cerevisiae Genes Whose Deletion Causes SyntheticEffects in Cells with Reduced Levels of the Nuclear Pif1 DNA Helicase | Stundon JL, Zakian VA | 10.1534/g3.115.021139 |