Product Description: AP-1/2 complex subunit beta, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.31 | 0.84 |
| Trophozoite | expressed | 0.33 | 0.79 |
| Schizont | expressed | 0.32 | 0.78 |
| Gametocyte | expressed | 0.30 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0528100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.959 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1242700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3I6
"Best" AlphaFill ligand hit: DTD (dithiane diol, Local RMSD=0.19) with 1E42 (Global RMSD=2.66)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100684
Most Similar Human Ortholog: C9J1E7
TM-align score: 0.98 | RMSD: 1.30
Seq Identity: 0.65 | Length: 577 / 929
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000006125 | adaptor related protein complex 2 subunit beta 1 |
| ENSG00000100280 | adaptor related protein complex 1 subunit beta 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 72 | 34 | 74 |
| disruptive | 11 | 39 | 24 | 55 |
| missense | 11 | 37 | 23 | 48 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 30 | 139 | 32 | 54 |
| disruptive | 21 | 98 | 50 | 151 |
| missense | 15 | 81 | 48 | 100 |
PlasmoDB Total SNPs: 328
Non-coding: 276 | Synonymous: 43 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 929 | Molecular Weight (kDa): 106.154
UniProt ID(s): Q8I3I6
PDB ID(s): None
Isoelectric Point: 5.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002553 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| InterPro | IPR009028 | Coatomer/calthrin adaptor appendage, C-terminal subdomain |
| InterPro | IPR013041 | Clathrin adaptor, appendage, Ig-like subdomain superfamily |
| InterPro | IPR015151 | Beta-adaptin appendage, C-terminal subdomain |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR016342 | AP-1/2/4 complex subunit beta |
| InterPro | IPR026739 | AP complex subunit beta |
| PFam | PF01602 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| PFam | PF09066 | Beta-adaptin appendage, C-terminal subdomain |
| Superfamily | SSF48371 | Armadillo-type fold |
| Superfamily | SSF49348 | Clathrin adaptor, appendage, Ig-like subdomain superfamily |
| Superfamily | SSF55711 | Coatomer/calthrin adaptor appendage, C-terminal subdomain |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 32098816 | The Plasmodium falciparum Artemisinin Susceptibility-Associated A P-2 Adaptin mu Subunit is Clathrin Independent and Essential for Schizont Maturation | Henrici RC, Edwards RL, ..., Sutherland CJ | 10.1128/mBio.02918-19 |