Genome location: Pf3D7_05_v3:1,162,969..1,165,509(-)
Genome classification: Core
Product Description: eukaryotic translation initiation factor 3 subunit E, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.99 | 0.55 |
| Trophozoite | expressed | 1.05 | 0.46 |
| Schizont | expressed | 0.26 | 0.83 |
| Gametocyte | possibly expressed | 0.41 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0528200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.128 | MFS: -3.124 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3I5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102060
Most Similar Human Ortholog: A0A7I2V5P9
TM-align score: 0.89 | RMSD: 2.46
Seq Identity: 0.26 | Length: 326 / 517
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000104408 | eukaryotic translation initiation factor 3 subunit E |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 27 | 12 | 30 |
| disruptive | 5 | 12 | 18 | 53 |
| missense | 5 | 12 | 15 | 40 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 56 | 16 | 26 |
| disruptive | 9 | 55 | 30 | 80 |
| missense | 7 | 41 | 22 | 49 |
PlasmoDB Total SNPs: 195
Non-coding: 162 | Synonymous: 25 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 517 | Molecular Weight (kDa): 61.419
UniProt ID(s): Q8I3I5
PDB ID(s): None
Isoelectric Point: 7.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000717 | Proteasome component (PCI) domain |
| InterPro | IPR016650 | Eukaryotic translation initiation factor 3 subunit E |
| InterPro | IPR019010 | Eukaryotic translation initiation factor 3 subunit E, N-terminal |
| InterPro | IPR036390 | Winged helix DNA-binding domain superfamily |
| PFam | PF01399 | Proteasome component (PCI) domain |
| Superfamily | SSF46785 | Winged helix DNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |