PF3D7_0528300

Genome location: Pf3D7_05_v3:1,166,047..1,169,378(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.01	1.00
Schizont	expressed	0.47	0.73
Gametocyte	not expressed	0.06	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0528300

Resistome Missense Mutations: P249H

Resistome Compounds with Missense Mutations: Artemisinin

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.62 | MFS: -2.418 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3I4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533156

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	35	18	44
disruptive	18	69	45	85
missense	17	68	45	79

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	64	22	40
disruptive	28	147	70	126
missense	26	139	64	99

PlasmoDB Total SNPs: 185

Non-coding: 141 | Synonymous: 23 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 496 | Molecular Weight (kDa): 58.826

UniProt ID(s): Q8I3I4

PDB ID(s): None

Isoelectric Point: 5.93

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A