Genome location: Pf3D7_05_v3:1,174,532..1,177,311(+)
Genome classification: Core
Product Description: F-actin-capping protein subunit alpha, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0008290 | F-actin capping protein complex |
| Function | GO:0051015 | actin filament binding |
| Process | GO:0030036 | actin cytoskeleton organization |
| Process | GO:0051693 | actin filament capping |
| Process | GO:0051016 | barbed-end actin filament capping |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.16 | 0.89 |
| Schizont | expressed | 0.17 | 0.88 |
| Gametocyte | expressed | 0.54 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0528500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.934 | MFS: -2.403 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1243100)
Modification: Mutated | RMgm-1157
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3I2
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=3.02) with 2QBY (Global RMSD=14.30)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102492
Most Similar Human Ortholog: P47755
TM-align score: 0.90 | RMSD: 2.21
Seq Identity: 0.19 | Length: 278 / 307
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000116489 | capping actin protein of muscle Z-line subunit alpha 1 |
| ENSG00000198898 | capping actin protein of muscle Z-line subunit alpha 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 13 | 7 | 20 |
| disruptive | 5 | 18 | 20 | 44 |
| missense | 5 | 18 | 20 | 41 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 27 | 15 | 31 |
| disruptive | 5 | 72 | 32 | 68 |
| missense | 5 | 63 | 27 | 52 |
PlasmoDB Total SNPs: 210
Non-coding: 195 | Synonymous: 10 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 307 | Molecular Weight (kDa): 36.449
UniProt ID(s): Q8I3I2
PDB ID(s): None
Isoelectric Point: 8.78
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002189 | F-actin-capping protein subunit alpha |
| InterPro | IPR037282 | F-actin-capping protein subunit alpha/beta |
| PFam | PF01267 | F-actin-capping protein subunit alpha |
| Superfamily | SSF90096 | F-actin-capping protein subunit alpha/beta |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 25565321 | Pivotal and distinct role for Plasmodium actin capping protein alpha during bloodinfection of the malaria parasite. | Ganter M, Rizopoulos Z, Schuler H, Matuschewski K | 10.1111/mmi.12922 |