Genome location: Pf3D7_05_v3:1,178,062..1,179,980(-)
Genome classification: Core
Product Description: peptidyl-prolyl cis-trans isomerase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 5.2.1.8 (Peptidylprolyl isomerase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0016018 | cyclosporin A binding |
| Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Process | GO:0006457 | protein folding |
| Process | GO:0000413 | protein peptidyl-prolyl isomerization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.05 | 0.97 |
| Trophozoite | possibly expressed | 0.04 | 0.97 |
| Schizont | not expressed | 0.01 | 0.99 |
| Gametocyte | possibly expressed | 0.06 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0528700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.996 | MFS: -1.833 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3I0
"Best" AlphaFill ligand hit: LSA (saccharin, Local RMSD=0.06) with 4N1O (Global RMSD=1.44)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.2.1.8 | peptidylprolyl isomerase | ATPNEMSDSPCMBFK506QAEGPKAla-ProjugloneSer-ProGPI-1046RNase T1Rapamycin... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102285
Most Similar Human Ortholog: Q9Y3C6
TM-align score: 0.95 | RMSD: 1.58
Seq Identity: 0.50 | Length: 165 / 204
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000137168 | peptidylprolyl isomerase like 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 131
Non-coding: 113 | Synonymous: 9 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 204 | Molecular Weight (kDa): 23.199
UniProt ID(s): Q8I3I0
PDB ID(s): None
Isoelectric Point: 5.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002130 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
| InterPro | IPR029000 | Cyclophilin-like domain superfamily |
| PFam | PF00160 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
| Superfamily | SSF50891 | Cyclophilin-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 22546550 | A family of cyclophilin-like molecular chaperones in Plasmodium falciparum. | Marin-Menendez A, Monaghan P, Bell A | 10.1016/j.molbiopara.2012.04.006 |