PF3D7_0528900

Genome location: Pf3D7_05_v3:1,183,850..1,186,249(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MLYSLCLLYITIAKTLS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	possibly expressed	0.01	1.00
Schizont	possibly expressed	0.01	0.99
Gametocyte	expressed	1.08	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0528900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.203 | MFS: -2.613 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4G6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533523

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	25	8	13
disruptive	3	20	20	59
missense	3	20	20	56

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	41	14	13
disruptive	4	66	35	68
missense	4	60	30	56

PlasmoDB Total SNPs: 201

Non-coding: 191 | Synonymous: 5 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 228 | Molecular Weight (kDa): 26.891

UniProt ID(s): C0H4G6

PDB ID(s): None

Isoelectric Point: 7.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A