Genome location: Pf3D7_05_v3:1,186,294..1,190,130(-)
Genome classification: Core
Product Description: T-cell immunomodulatory protein homolog, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0009986 | cell surface |
| Component | GO:0044228 | host cell surface |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.50 | 0.75 |
| Trophozoite | expressed | 0.42 | 0.75 |
| Schizont | expressed | 0.38 | 0.75 |
| Gametocyte | expressed | 0.33 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0529000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.901 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1243600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3H7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103304
Most Similar Human Ortholog: F5GXC5
TM-align score: 0.86 | RMSD: 2.71
Seq Identity: 0.28 | Length: 434 / 719
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000129636 | integrin alpha FG-GAP repeat containing 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 33 | 19 | 45 |
| disruptive | 8 | 38 | 28 | 43 |
| missense | 8 | 37 | 27 | 37 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 81 | 28 | 35 |
| disruptive | 14 | 83 | 43 | 104 |
| missense | 11 | 71 | 36 | 80 |
PlasmoDB Total SNPs: 226
Non-coding: 191 | Synonymous: 26 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 719 | Molecular Weight (kDa): 82.905
UniProt ID(s): Q8I3H7
PDB ID(s): None
Isoelectric Point: 5.06
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013517 | FG-GAP repeat |
| InterPro | IPR024881 | T-cell immunomodulatory protein |
| PFam | PF13517 | FG-GAP repeat |
| Superfamily | SSF69318 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 34987497 | Plasmodium berghei-Released Factor, PbTIP, Modulates the Host Innate ImmuneResponses. | Kalia I, Anand R, ..., Singh AP | 10.3389/fimmu.2021.699887 |