Genome location: Pf3D7_05_v3:1,190,980..1,192,000(-)
Genome classification: Core
Product Description: thioredoxin-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.09 | 0.96 |
| Trophozoite | not expressed | 0.72 | 0.60 |
| Schizont | not expressed | 0.20 | 0.88 |
| Gametocyte | not expressed | 0.41 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0529100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.173 | MFS: -3.487 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1243700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3H6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 10 | 4 | 11 |
| disruptive | 3 | 23 | 15 | 17 |
| missense | 2 | 21 | 14 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 21 | 6 | 15 |
| disruptive | 10 | 39 | 19 | 39 |
| missense | 7 | 33 | 16 | 28 |
PlasmoDB Total SNPs: 60
Non-coding: 50 | Synonymous: 4 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 183 | Molecular Weight (kDa): 22.056
UniProt ID(s): Q8I3H6
PDB ID(s): None
Isoelectric Point: 9.16
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 22144892 | A systematic screen to discover and analyze apicoplast proteins identifies aconserved and essential protein import factor. | Sheiner L, Demerly JL, ..., Striepen B | 10.1371/journal.ppat.1002392 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |