Product Description: sugar transporter, putative
SignalP Peptide: N/A
# Transmembrane Domains: 12
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0005887 | integral component of plasma membrane |
| Component | GO:0016020 | membrane |
| Function | GO:0005351 | carbohydrate:proton symporter activity |
| Process | GO:0008643 | carbohydrate transport |
| Process | GO:0071702 | organic substance transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.12 | 0.93 |
| Schizont | expressed | 0.04 | 0.97 |
| Gametocyte | expressed | 0.14 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0529200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.98 | MFS: -2.781 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3H5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104151
Most Similar Human Ortholog: A0A2I3JL00
TM-align score: 0.81 | RMSD: 2.92
Seq Identity: 0.14 | Length: 447 / 548
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000168389 | major facilitator superfamily domain containing 2A |
| ENSG00000205639 | major facilitator superfamily domain containing 2B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 35 | 27 | 35 |
| disruptive | 41 | 79 | 38 | 115 |
| missense | 27 | 71 | 36 | 99 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 73 | 28 | 40 |
| disruptive | 59 | 156 | 96 | 141 |
| missense | 35 | 139 | 82 | 113 |
PlasmoDB Total SNPs: 202
Non-coding: 126 | Synonymous: 28 | Nonsynonymous: 47 | Stop Codon: 1
Protein Length: 548 | Molecular Weight (kDa): 63.769
UniProt ID(s): Q8I3H5
PDB ID(s): None
Isoelectric Point: 8.65
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR036259 | MFS transporter superfamily |
| InterPro | IPR039672 | Lactose permease-like |
| PFam | PF13347 | N/A |
| Superfamily | SSF103473 | MFS transporter superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |