PF3D7_0529400 (AKIT5)

Genome location: Pf3D7_05_v3:1,198,563..1,205,743(+)

Genome classification: Core

Function and Localization

Product Description: apicomplexan kinetochore protein 5, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0529400.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.175 | MFS: -2.709 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1243900)

Modification: Tagged | RMgm-5117

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZXE1

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532682

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 482

Non-coding: 315 | Synonymous: 96 | Nonsynonymous: 71 | Stop Codon: 0

Protein Information

Protein Length: 1582 | Molecular Weight (kDa): 185.373

UniProt ID(s): A0A143ZXE1

PDB ID(s): None

Isoelectric Point: 7.09

Protein Domain Annotations: