Product Description: cell cycle regulator protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Process | GO:0001731 | formation of translation preinitiation complex |
| Process | GO:0051726 | regulation of cell cycle |
| Process | GO:0002188 | translation reinitiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.05 | 0.98 |
| Trophozoite | not expressed | 0.10 | 0.94 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | not expressed | 0.05 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0529500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.5 | MFS: -2.461 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1244000)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1244000)
Modification: Disrupted | RMgm-3387
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3H2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9ULC4 | Malignant T-cell-amplified sequence 1 | HOGENOM, OMA, OrthoDB, OrthoMCL BLAST | US11724989, Example 5US11724989, Example 6US11724989, Example 10US11724989, Example 17... |
Ortholog Group (OrthoMCL): OG6_101211
Most Similar Human Ortholog: A0A3B3IRV3
TM-align score: 0.96 | RMSD: 1.12
Seq Identity: 0.46 | Length: 179 / 179
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101898 | MCTS family member 2, pseudogene |
| ENSG00000232119 | MCTS1 re-initiation and release factor |
| ENSG00000288295 | MCTS1 re-initiation and release factor |
Protein Length: 179 | Molecular Weight (kDa): 20.259
UniProt ID(s): Q8I3H2
PDB ID(s): None
Isoelectric Point: 8.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002478 | PUA domain |
| InterPro | IPR004521 | Uncharacterised domain CHP00451 |
| InterPro | IPR015947 | PUA-like superfamily |
| InterPro | IPR016437 | MCT-1/Tma20 |
| InterPro | IPR041366 | Pre-PUA domain |
| PFam | PF01472 | PUA domain |
| PFam | PF17832 | Pre-PUA domain |
| Superfamily | SSF88697 | PUA-like superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 20 | 5 | 14 |
| disruptive | 1 | 8 | 7 | 19 |
| missense | 1 | 8 | 7 | 17 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 22 | 15 | 12 |
| disruptive | 2 | 23 | 20 | 33 |
| missense | 1 | 22 | 17 | 25 |
PlasmoDB Total SNPs: 142
Non-coding: 130 | Synonymous: 8 | Nonsynonymous: 3 | Stop Codon: 1
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |