PF3D7_0529700

Genome location: Pf3D7_05_v3:1,208,695..1,212,893(-)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	not expressed	0.21	0.88
Schizont	not expressed	0.08	0.95
Gametocyte	not expressed	0.27	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0529700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.177 | MFS: -2.815 | #Insertions: 0

PlasmoGEM Phenotype: Insufficient data (Pb ortholog: PBANKA_1244100)

Relative Growth Rate: 0.37 ± 0.78
Confidence: 1.87

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3H1

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.63) with 6JWR (Global RMSD=20.17)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_121753

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	64	27	56
disruptive	22	101	63	146
missense	20	100	60	131

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	104	47	63
disruptive	46	230	115	215
missense	34	201	104	159

PlasmoDB Total SNPs: 237

Non-coding: 134 | Synonymous: 63 | Nonsynonymous: 40 | Stop Codon: 0

Protein Information

Protein Length: 986 | Molecular Weight (kDa): 117.792

UniProt ID(s): Q8I3H1

PDB ID(s): None

Isoelectric Point: 8.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR030417	Membrane-spanning 4-domains subfamily A
PFam	N/A	N/A
Superfamily	N/A	N/A