PF3D7_0529900

Genome location: Pf3D7_05_v3:1,219,683..1,223,261(-)

Genome classification: Core

Function and Localization

Product Description: RING zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.34	0.43
Trophozoite	expressed	0.81	0.56
Schizont	expressed	1.07	0.43
Gametocyte	expressed	1.24	0.38

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0529900

Resistome Missense Mutations: C236F

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 4 (2 missense, 2 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.773 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1244300)

Relative Growth Rate: 1.00 ± 0.08
Confidence: 6.38

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1244300)

Modification: Disrupted | RMgm-3388

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3G9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_132945

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	doubleton	singleton
synonymous	0	0
disruptive	1	2
missense	0	0

PlasmoDB Total SNPs: 162

Non-coding: 148 | Synonymous: 12 | Nonsynonymous: 1 | Stop Codon: 1

Protein Information

Protein Length: 284 | Molecular Weight (kDa): 34.146

UniProt ID(s): Q8I3G9

PDB ID(s): None

Isoelectric Point: 9.78

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001841	Zinc finger, RING-type
PFam	PF13639	Zinc finger, RING-type
Superfamily	SSF57850	N/A