PF3D7_0530000

Genome location: Pf3D7_05_v3:1,223,345..1,225,947(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.23	0.88
Trophozoite	not expressed	0.81	0.56
Schizont	not expressed	0.17	0.89
Gametocyte	not expressed	0.44	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0530000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.955 | MFS: -2.303 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1244400)

Relative Growth Rate: 1.06 ± 0.15
Confidence: 5.18

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1244400)

Modification: Disrupted | RMgm-3389

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3G7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532827

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	1
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	rare	singleton
synonymous	1	0
disruptive	1	1
missense	0	0

PlasmoDB Total SNPs: 159

Non-coding: 156 | Synonymous: 0 | Nonsynonymous: 2 | Stop Codon: 1

Protein Information

Protein Length: 97 | Molecular Weight (kDa): 11.54

UniProt ID(s): Q8I3G7

PDB ID(s): None

Isoelectric Point: 4.34

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A