About Gene List

PF3D7_0530100 (SYN6)

Genome location: Pf3D7_05_v3:1,225,877..1,228,191(+)

Genome classification: Core

Function and Localization

Product Description: SNARE protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0031201 SNARE complex
Component GO:0012505 endomembrane system
Component GO:0016021 integral component of membrane
Function GO:0005484 SNAP receptor activity
Function GO:0000149 SNARE binding
Process GO:0006886 intracellular protein transport
Process GO:0048278 vesicle docking
Process GO:0006906 vesicle fusion
Process GO:0016192 vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.13 0.93
Trophozoite not expressed 0.05 0.97
Schizont possibly expressed 0.05 0.97
Gametocyte not expressed 0.04 0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0530100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.125 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1244500)

  • Relative Growth Rate: 0.19 ± 0.16
  • Confidence: 5.07

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3G6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103098

Most Similar Human Ortholog: I3L305

TM-align score: 0.76 | RMSD: 1.99

Seq Identity: 0.13 | Length: 97 / 225

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000170310 syntaxin 8

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 11 9 12
disruptive 3 21 13 41
missense 3 21 13 37

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 24 8 23
disruptive 8 50 31 55
missense 7 43 27 37

PlasmoDB Total SNPs: 93

Non-coding: 75 | Synonymous: 16 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 225 | Molecular Weight (kDa): 26.69

UniProt ID(s): Q0ZAF9, Q8I3G6

PDB ID(s): None

Isoelectric Point: 5.46

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily SSF58038 N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
24664517 Definition of culture conditions for Arxula adeninivorans, a rational basis forstudying heterologous gene expression in this dimorphic yeast Stockmann C, Palmen TG, ..., Buchs J 10.1007/s10295-014-1433-4
30995911 Hospital-derived antibody profiles of malaria patients in Southwest India Venkatesh A, Jain A, ..., Rathod PK 10.1186/s12936-019-2771-5