Genome location: Pf3D7_05_v3:1,229,052..1,231,469(-)
Genome classification: Core
Product Description: phosphoenolpyruvate/phosphate translocator
SignalP Peptide: MNVLTRTLIITIFFNLQIYIGKC
# Transmembrane Domains: 7
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0020011 | apicoplast |
| Component | GO:0031353 | integral component of plastid inner membrane |
| Component | GO:0009528 | plastid inner membrane |
| Function | GO:0005457 | GDP-fucose transmembrane transporter activity |
| Function | GO:0015297 | antiporter activity |
| Function | GO:0061513 | glucose 6-phosphate:inorganic phosphate antiporter activity |
| Function | GO:0005338 | nucleotide-sugar transmembrane transporter activity |
| Function | GO:0022857 | transmembrane transporter activity |
| Function | GO:0009670 | triose-phosphate:phosphate antiporter activity |
| Process | GO:0046323 | glucose import |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.09 | 0.96 |
| Trophozoite | expressed | 0.77 | 0.58 |
| Schizont | expressed | 0.29 | 0.81 |
| Gametocyte | expressed | 0.43 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0530200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.512 | MFS: -3.138 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1244600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I0U9
"Best" AlphaFill ligand hit: 3PG (3-phosphoglyceric acid, Local RMSD=0.21) with 5Y79 (Global RMSD=4.04)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101650
Most Similar Human Ortholog: Q96K37
TM-align score: 0.70 | RMSD: 3.41
Seq Identity: 0.20 | Length: 328 / 524
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000127526 | solute carrier family 35 member E1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 38 | 14 | 30 |
| disruptive | 0 | 38 | 25 | 63 |
| missense | 0 | 38 | 23 | 55 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 63 | 26 | 23 |
| disruptive | 9 | 124 | 66 | 172 |
| missense | 6 | 99 | 52 | 109 |
PlasmoDB Total SNPs: 109
Non-coding: 88 | Synonymous: 15 | Nonsynonymous: 5 | Stop Codon: 1
Protein Length: 524 | Molecular Weight (kDa): 59.789
UniProt ID(s): Q8I0U9
PDB ID(s): None
Isoelectric Point: 10.45
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004853 | Sugar phosphate transporter domain |
| PFam | PF03151 | Sugar phosphate transporter domain |
| Superfamily | SSF103481 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16760253 | Membrane transporters in the relict plastid of malaria parasites. | Mullin KA, Lim L, ..., McFadden GI | 10.1073/pnas.0602293103 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |