Genome location: Pf3D7_05_v3:1,231,929..1,238,086(+)
Genome classification: Core
Product Description: PhIL1-interacting candidate PIC6
SignalP Peptide: N/A
# Transmembrane Domains: 11
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0070258 | inner membrane pellicle complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.05 | 0.97 |
| Trophozoite | possibly expressed | 0.41 | 0.76 |
| Schizont | expressed | 1.03 | 0.49 |
| Gametocyte | expressed | 0.68 | 0.62 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0530300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.452 | #Insertions: 10
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H4G8
"Best" AlphaFill ligand hit: ABH (2(s)-amino-6-boronohexanoic acid, Local RMSD=0.79) with 3MMR (Global RMSD=40.55)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 97 | 50 | 105 |
| disruptive | 37 | 251 | 129 | 328 |
| missense | 29 | 221 | 116 | 281 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 22 | 179 | 64 | 107 |
| disruptive | 113 | 557 | 233 | 548 |
| missense | 65 | 450 | 186 | 322 |
PlasmoDB Total SNPs: 339
Non-coding: 184 | Synonymous: 102 | Nonsynonymous: 53 | Stop Codon: 0
Protein Length: 1446 | Molecular Weight (kDa): 173.266
UniProt ID(s): C0H4G8
PDB ID(s): None
Isoelectric Point: 9.76
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 33830607 | Identification of novel inner membrane complex and apical annuli proteins of themalaria parasite Plasmodium falciparum. | Wichers JS, Wunderlich J, ..., Gilberger TW | 10.1111/cmi.13341 |