PF3D7_0530400

Genome location: Pf3D7_05_v3:1,238,120..1,243,999(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	expressed	0.28	0.84
Schizont	not expressed	0.13	0.92
Gametocyte	possibly expressed	0.49	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0530400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.034 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1244800)

Relative Growth Rate: 0.21 ± 0.23
Confidence: 4.32

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3G4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532676

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	22	109	44	124
disruptive	104	344	166	372
missense	75	290	148	306

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	47	191	82	116
disruptive	203	627	241	555
missense	139	522	182	345

PlasmoDB Total SNPs: 287

Non-coding: 47 | Synonymous: 127 | Nonsynonymous: 113 | Stop Codon: 0

Protein Information

Protein Length: 1784 | Molecular Weight (kDa): 214.781

UniProt ID(s): Q8I3G4

PDB ID(s): None

Isoelectric Point: 8.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A