PF3D7_0530500

Genome location: Pf3D7_05_v3:1,244,751..1,248,359(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: MLKFIYIHFFYVYILLCLCCGATS

# Transmembrane Domains: 13

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.01	0.99
Gametocyte	possibly expressed	0.24	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0530500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.423 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1244900)

Relative Growth Rate: 1.00 ± 0.08
Confidence: 6.46

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1244900)

Modification: Disrupted | RMgm-3393

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4G9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532532

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	68	40	75
disruptive	23	171	79	216
missense	19	165	78	195

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	24	128	56	75
disruptive	55	364	134	279
missense	39	315	116	209

PlasmoDB Total SNPs: 147

Non-coding: 75 | Synonymous: 46 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 1009 | Molecular Weight (kDa): 123.359

UniProt ID(s): C0H4G9

PDB ID(s): None

Isoelectric Point: 8.91

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011641	Tyrosine-protein kinase ephrin type A/B receptor-like
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095