About Gene List

PF3D7_0530600

Genome location: Pf3D7_05_v3:1,248,232..1,250,252(-)

Genome classification: Core

Function and Localization

Product Description: XAP-5 DNA binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus
Process GO:0006325 chromatin organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.30 0.86
Trophozoite expressed 0.39 0.77
Schizont expressed 0.06 0.96
Gametocyte expressed 0.29 0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0530600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.189 | MFS: -2.653 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3G2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102806

Most Similar Human Ortholog: Q14320

TM-align score: 0.55 | RMSD: 3.54

Seq Identity: 0.39 | Length: 212 / 447

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000071859 family with sequence similarity 50 member A
ENSG00000145945 family with sequence similarity 50 member B

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 16 25 10 32
disruptive 36 68 42 76
missense 14 46 33 49

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 23 53 15 26
disruptive 61 150 47 122
missense 27 103 27 65

PlasmoDB Total SNPs: 173

Non-coding: 82 | Synonymous: 64 | Nonsynonymous: 27 | Stop Codon: 0

Protein Information

Protein Length: 447 | Molecular Weight (kDa): 52.034

UniProt ID(s): Q8I3G2

PDB ID(s): None

Isoelectric Point: 8.62

Protein Domain Annotations:

Source Family ID Description
InterPro IPR007005 XAP5 protein
PFam PF04921 XAP5 protein
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104