PF3D7_0530700

Genome location: Pf3D7_05_v3:1,250,370..1,254,901(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.40	0.81
Trophozoite	expressed	0.54	0.71
Schizont	possibly expressed	0.09	0.95
Gametocyte	possibly expressed	0.54	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0530700

Resistome Missense Mutations: S947A

Resistome Compounds with Missense Mutations: BCH070

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.009 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3G1

"Best" AlphaFill ligand hit: SAH (s-adenosyl-l-homocysteine, Local RMSD=2.69) with 4KWC (Global RMSD=3.54)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_184010

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	68	27	57
disruptive	65	237	126	238
missense	38	180	101	196

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	110	40	55
disruptive	142	418	144	326
missense	80	328	121	204

PlasmoDB Total SNPs: 235

Non-coding: 49 | Synonymous: 98 | Nonsynonymous: 86 | Stop Codon: 2

Protein Information

Protein Length: 1083 | Molecular Weight (kDa): 128.124

UniProt ID(s): Q8I3G1

PDB ID(s): None

Isoelectric Point: 6.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase
PFam	N/A	N/A
Superfamily	SSF53335	S-adenosyl-L-methionine-dependent methyltransferase