Genome location: Pf3D7_05_v3:1,254,200..1,255,290(-)
Genome classification: Core
Product Description: dolichol-phosphate mannosyltransferase subunit 3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: 2.4.1.83 (Dolichyl-phosphate beta-D-mannosyltransferase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0033185 | dolichol-phosphate-mannose synthase complex |
| Process | GO:0006506 | GPI anchor biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.00 | 1.00 |
| Trophozoite | no data | 0.02 | 0.99 |
| Schizont | no data | 0.00 | 1.00 |
| Gametocyte | no data | 0.04 | 0.97 |
More info:
No corresponding Pf3D7v3 gene ID in resistome database
Zhang Phenotype: N/A
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZVA5
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.4.1.83 | dolichyl-phosphate beta-D-mannosyltransferase | ATPADPUDPAMPGTPGDPUTPNEMUMPGMPHgCl2CuSO4... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104618
Most Similar Human Ortholog: Q9P2X0
TM-align score: 0.40 | RMSD: 3.45
Seq Identity: 0.09 | Length: 56 / 90
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000179085 | dolichyl-phosphate mannosyltransferase subunit 3, regulatory |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 36
Non-coding: 34 | Synonymous: 0 | Nonsynonymous: 1 | Stop Codon: 1
Protein Length: 90 | Molecular Weight (kDa): 10.6
UniProt ID(s): A0A143ZVA5
PDB ID(s): None
Isoelectric Point: 10.37
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013174 | Dolichol-phosphate mannosyltransferase subunit 3 |
| PFam | PF08285 | Dolichol-phosphate mannosyltransferase subunit 3 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 33255655 | Yil102c-A is a Functional Homologue of the DPMII Subunit of Dolichyl PhosphateMannose Synthase in Saccharomyces cerevisiae | Pilsyk S, Perlinska-Lenart U, ..., Kruszewska JS | 10.3390/ijms21238938 |
| 26299246 | Dolichol phosphate mannose synthase from the pathogenic yeast Candida albicans isa multimeric enzyme | Juchimiuk M, Kruszewska J, Palamarczyk G | 10.1016/j.bbagen.2015.08.012 |