About Gene List

PF3D7_0530800

Genome location: Pf3D7_05_v3:1,255,012..1,257,579(+)

Genome classification: Core

Function and Localization

Product Description: CPW-WPC family protein

SignalP Peptide: MDKFFFFFFFFFFCFYFEISFC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.00 1.00
Trophozoite expressed 0.02 0.99
Schizont expressed 0.02 0.99
Gametocyte expressed 0.69 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0530800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.343 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4H0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146158

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 17 6 25
disruptive 5 23 9 44
missense 4 21 7 40

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 33 9 18
disruptive 8 53 30 73
missense 5 44 25 56

PlasmoDB Total SNPs: 136

Non-coding: 123 | Synonymous: 9 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 254 | Molecular Weight (kDa): 29.676

UniProt ID(s): C0H4H0

PDB ID(s): None

Isoelectric Point: 4.59

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006387 CPW-WPC domain
PFam PF09717 CPW-WPC domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g