Genome location: Pf3D7_05_v3:1,257,680..1,266,372(-)
Genome classification: Core
Product Description: formin 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
| Component | GO:0005923 | bicellular tight junction |
| Function | GO:0003779 | actin binding |
| Process | GO:0030036 | actin cytoskeleton organization |
| Process | GO:0045010 | actin nucleation |
| Process | GO:0008154 | actin polymerization or depolymerization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.26 | 0.87 |
| Schizont | expressed | 1.37 | 0.41 |
| Gametocyte | expressed | 0.80 | 0.60 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0530900
Resistome Missense Mutations: D180E
Resistome Compounds with Missense Mutations: MMV019662
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.913 | MFS: -2.924 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1245300)
Modification: Tagged | RMgm-4479
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I3F9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 27 | 130 | 78 | 152 |
| disruptive | 116 | 378 | 179 | 433 |
| missense | 80 | 338 | 172 | 389 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 44 | 251 | 91 | 173 |
| disruptive | 194 | 682 | 280 | 529 |
| missense | 132 | 593 | 257 | 424 |
PlasmoDB Total SNPs: 303
Non-coding: 41 | Synonymous: 144 | Nonsynonymous: 118 | Stop Codon: 0
Protein Length: 2675 | Molecular Weight (kDa): 309.475
UniProt ID(s): Q8I3F9
PDB ID(s): None
Isoelectric Point: 8.36
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| InterPro | IPR015425 | Formin, FH2 domain |
| PFam | PF02181 | Formin, FH2 domain |
| Superfamily | SSF101447 | Tetratricopeptide-like helical domain superfamily |
| Superfamily | SSF48452 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18329618 | A malaria parasite formin regulates actin polymerization and localizes to theparasite-erythrocyte moving junction during invasion. | Baum J, Tonkin CJ, ..., Cowman AF | 10.1016/j.chom.2008.02.006 |
| 30753127 | Three F-actin assembly centers regulate organelle inheritance, cell-cellcommunication and motility in Toxoplasma gondii | Tosetti N, Dos Santos Pacheco N, Soldati-Favre D, Jacot D | 10.7554/eLife.42669 |
| 8701605 | Identification of a class of Saccharomyces cerevisiae mutants defective in fattyacid repression of gene transcription and analysis of the frm2 gene | McHale MW, Kroening KD, Bernlohr DA | 10.1002/(SICI)1097-0061(19960330)12:4<319::AID-YEA914>3.0.CO;2-# |
| 37596377 | Plasmodium falciparum formins are essential for invasion and sexual stagedevelopment | Collier S, Pietsch E, ..., Dixon MWA | 10.1038/s42003-023-05233-y |