PF3D7_0531000

Genome location: Pf3D7_05_v3:1,266,892..1,269,589(+)

Genome classification: Core

Function and Localization

Product Description: SURF1 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.92
Trophozoite	not expressed	0.31	0.81
Schizont	not expressed	0.28	0.81
Gametocyte	not expressed	0.48	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0531000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -3.156 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3F8

"Best" AlphaFill ligand hit: R78 (4-{[(7r)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-n-(1-methylpiperidin-4-yl)benzamide, Local RMSD=14.94) with 4PY6 (Global RMSD=23.92)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_137145

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	40	19	42
disruptive	17	135	64	119
missense	17	132	60	107

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	72	30	39
disruptive	45	237	100	182
missense	35	218	91	128

PlasmoDB Total SNPs: 109

Non-coding: 55 | Synonymous: 30 | Nonsynonymous: 24 | Stop Codon: 0

Protein Information

Protein Length: 709 | Molecular Weight (kDa): 85.13

UniProt ID(s): Q8I3F8

PDB ID(s): None

Isoelectric Point: 9.76

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002994	Surfeit locus 1/Shy1
PFam	PF02104	Surfeit locus 1/Shy1
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21