PF3D7_0531100

Genome location: Pf3D7_05_v3:1,269,832..1,278,893(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0531100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.184 | #Insertions: 13

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3F7

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=8.90) with 3CLV (Global RMSD=23.97)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533751

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 386

Non-coding: 42 | Synonymous: 173 | Nonsynonymous: 170 | Stop Codon: 1

Protein Information

Protein Length: 2698 | Molecular Weight (kDa): 325.264

UniProt ID(s): Q8I3F7

PDB ID(s): None

Isoelectric Point: 9.34

Protein Domain Annotations: