PF3D7_0531200

Genome location: Pf3D7_05_v3:1,279,189..1,280,883(-)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein S16, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005763	mitochondrial small ribosomal subunit
Component	GO:0015935	small ribosomal subunit
Function	GO:0003735	structural constituent of ribosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.27	0.83
Schizont	not expressed	0.11	0.93
Gametocyte	possibly expressed	0.38	0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0531200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -2.9 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3F6

"Best" AlphaFill ligand hit: HEM (heme, Local RMSD=2.92) with 8AE8 (Global RMSD=27.56)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101089

Most Similar Human Ortholog: A6ND22

TM-align score: 0.78 | RMSD: 1.72

Seq Identity: 0.26 | Length: 87 / 213

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000182180	mitochondrial ribosomal protein S16

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	0	1
missense	0	0	0	0

Any inclusion in genotype call

variant type	rare	doubleton	singleton
synonymous	0	0	0
disruptive	1	1	1
missense	0	0	0

PlasmoDB Total SNPs: 71

Non-coding: 55 | Synonymous: 13 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 213 | Molecular Weight (kDa): 25.902

UniProt ID(s): Q8I3F6

PDB ID(s): None

Isoelectric Point: 10.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000307	Ribosomal protein S16
InterPro	IPR023803	Ribosomal protein S16 domain superfamily
PFam	PF00886	Ribosomal protein S16
Superfamily	SSF54565	Ribosomal protein S16 domain superfamily