PF3D7_0531300

Genome location: Pf3D7_05_v3:1,281,104..1,282,484(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.25	0.85
Schizont	possibly expressed	0.34	0.79
Gametocyte	possibly expressed	0.32	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0531300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.229 | MFS: -2.266 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1245700)

Relative Growth Rate: 0.94 ± 0.19
Confidence: 4.69

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1245700)

Modification: Disrupted | RMgm-3395

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3F5

"Best" AlphaFill ligand hit: UPG (uridine-5'-diphosphate-glucose, Local RMSD=17.80) with 7MSN (Global RMSD=14.70)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532594

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	11	7	16
disruptive	8	41	29	37
missense	8	41	28	35

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	20	8	15
disruptive	17	85	36	69
missense	15	77	29	50

PlasmoDB Total SNPs: 62

Non-coding: 37 | Synonymous: 12 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 295 | Molecular Weight (kDa): 35.292

UniProt ID(s): Q8I3F5

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A