PF3D7_0531400

Genome location: Pf3D7_05_v3:1,282,377..1,286,689(-)

Genome classification: Core

Function and Localization

Product Description: G-patch domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0071008	U2-type post-mRNA release spliceosomal complex
Process	GO:0000390	spliceosomal complex disassembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.39	0.81
Trophozoite	not expressed	0.49	0.72
Schizont	possibly expressed	0.13	0.92
Gametocyte	not expressed	0.36	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0531400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -3.207 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1245800)

Relative Growth Rate: 0.10 ± 0.12
Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3F4

"Best" AlphaFill ligand hit: TQP (, Local RMSD=0.61) with 5U21 (Global RMSD=21.48)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533746

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	53	21	55
disruptive	56	242	108	210
missense	52	240	101	192

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	85	37	62
disruptive	120	418	150	304
missense	107	375	127	225

PlasmoDB Total SNPs: 232

Non-coding: 139 | Synonymous: 41 | Nonsynonymous: 52 | Stop Codon: 0

Protein Information

Protein Length: 1171 | Molecular Weight (kDa): 142.141

UniProt ID(s): Q8I3F4

PDB ID(s): None

Isoelectric Point: 7.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000467	G-patch domain
PFam	PF01585	G-patch domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104