Genome location: Pf3D7_05_v3:1,300,188..1,302,740(+)
Genome classification: Core
Product Description: early transcribed membrane protein 5
SignalP Peptide: MRFSKVFSFFAFFIALKYFNRCLG
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020005 | symbiont-containing vacuole membrane |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.74 | 0.14 |
| Trophozoite | expressed | 3.79 | 0.02 |
| Schizont | expressed | 0.93 | 0.58 |
| Gametocyte | expressed | 0.66 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0532100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.998 | MFS: -2.57 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K7X4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 107
Non-coding: 90 | Synonymous: 10 | Nonsynonymous: 7 | Stop Codon: 0
Protein Length: 181 | Molecular Weight (kDa): 19.03
UniProt ID(s): A0A5K1K7X4, Q25731
PDB ID(s): None
Isoelectric Point: 5.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006389 | Early transcribed membrane protein (ETRAMP) |
| PFam | PF09716 | Early transcribed membrane protein (ETRAMP) |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 12686607 | etramps, a new Plasmodium falciparum gene family coding for developmentallyregulated and highly charged membrane proteins located at the parasite-host cellinterface. | Spielmann T, Fergusen DJ, Beck HP | 10.1091/mbc.e02-04-0240 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18937849 | Interaction of an atypical Plasmodium falciparum ETRAMP with humanapolipoproteins. | Vignali M, McKinlay A, ..., Fields S | 10.1186/1475-2875-7-211 |
| 29138437 | Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the innermembrane complex and is required for Plasmodium parasite development. | Saini E, Zeeshan M, ..., Tewari R | 10.1038/s41598-017-15781-z |
| 35883064 | Etramp5 as a useful serological marker in children to assess the immediateeffects of mass drug campaigns for malaria | Druetz T, van den Hoogen L, ..., Eisele TP | 10.1186/s12879-022-07616-8 |
| 33183292 | Sero-epidemiological evaluation of malaria transmission in The Gambia before and after mass drug administration | Wu L, Mwesigwa J, ..., Drakeley C | 10.1186/s12916-020-01785-6 |
| 32972398 | Antibody responses to a suite of novel serological markers for malaria surveillance demonstrate strong correlation with clinical and parasitological infection across seasons and transmission settings in The Gambia | Wu L, Mwesigwa J, ..., Drakeley C | 10.1186/s12916-020-01724-5 |
| 37693871 | Analytical approaches for antimalarial antibody responses to confirm historicaland recent malaria transmission: an example from the Philippines | Macalinao MLM, Fornace KM, ..., Drakeley CJ | 10.1016/j.lanwpc.2023.100792 |
| 35198913 | Serological evaluation of the effectiveness of reactive focal mass drugadministration and reactive vector control to reduce malaria transmission inZambezi Region, Namibia: Results from a secondary analysis of a clusterrandomised trial | Wu L, Hsiang MS, ..., Kleinschmidt I | 10.1016/j.eclinm.2022.101272 |