About Gene List

PF3D7_0532200

Genome location: Pf3D7_05_v3:1,303,429..1,304,634(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTc), unknown function

SignalP Peptide: MIICTFLKGNFFSLICVLLFTVMIHKKKSG

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.09 0.96
Trophozoite not expressed 0.12 0.92
Schizont expressed 0.07 0.95
Gametocyte expressed 0.09 0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0532200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.599 | MFS: -2.405 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3F2

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=0.65) with 5ZQ4 (Global RMSD=15.37)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215316

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 11 1 10
disruptive 23 44 13 35
missense 21 44 12 32

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 19 3 17
disruptive 36 83 31 61
missense 31 73 27 38

PlasmoDB Total SNPs: 94

Non-coding: 64 | Synonymous: 12 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 226 | Molecular Weight (kDa): 27.3

UniProt ID(s): Q8I3F2

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006526 Exported protein, PHISTa/b/c, conserved domain, Plasmodium
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12