About Gene List

PF3D7_0532300

Genome location: Pf3D7_05_v3:1,307,099..1,310,572(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTb), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0030430 host cell cytoplasm
Component GO:0044228 host cell surface
Component GO:0005634 nucleus
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 1.28 0.57
Trophozoite expressed 0.90 0.61
Schizont expressed 0.20 0.89
Gametocyte not expressed 0.15 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0532300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.751 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3F1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_131849

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 12 8 17
disruptive 19 23 15 59
missense 19 23 14 47

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 25 14 23
disruptive 33 61 52 129
missense 27 48 39 71

PlasmoDB Total SNPs: 158

Non-coding: 112 | Synonymous: 20 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 509 | Molecular Weight (kDa): 60.188

UniProt ID(s): B2BZB8, B2BZB9, Q8I3F1

PDB ID(s): None

Isoelectric Point: 4.68

Protein Domain Annotations:

Source Family ID Description
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
27022937 The Plasmodium PHIST and RESA-Like Protein Families of Human and Rodent MalariaParasites. Moreira CK, Naissant B, ..., Templeton TJ 10.1371/journal.pone.0152510
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596
33774908 Characterisation of complexes formed by parasite proteins exported into the hostcell compartment of Plasmodium falciparum infected red blood cells. Jonsdottir TK, Counihan NA, ..., Gilson PR 10.1111/cmi.13332