PF3D7_0532500

Genome location: Pf3D7_05_v3:1,316,238..1,316,874(+)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: MNINIFNFFIFIIYLHYYNKISS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0532500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.121 | MFS: -3.3 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I3E9

"Best" AlphaFill ligand hit: LMR (l-malate, Local RMSD=0.82) with 4KUF (Global RMSD=15.64)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532688

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 32

Non-coding: 17 | Synonymous: 8 | Nonsynonymous: 6 | Stop Codon: 1

Protein Information

Protein Length: 121 | Molecular Weight (kDa): 14.709

UniProt ID(s): Q8I3E9

PDB ID(s): None

Isoelectric Point: 9.93

Protein Domain Annotations: