About Gene List

PF3D7_0532600

Genome location: Pf3D7_05_v3:1,317,882..1,319,382(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: MNILKLYINISVLLFFIISKYNP

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0044164 host cell cytosol

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.00 1.00
Trophozoite expressed 0.03 0.99
Schizont expressed 0.00 1.00
Gametocyte not expressed 0.01 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0532600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.121 | MFS: -3.222 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4H1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533054

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 5 3 7
disruptive 41 25 10 20
missense 30 19 10 12

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 8 8 8
disruptive 46 44 17 44
missense 33 33 11 23

PlasmoDB Total SNPs: 164

Non-coding: 103 | Synonymous: 16 | Nonsynonymous: 43 | Stop Codon: 2

Protein Information

Protein Length: 161 | Molecular Weight (kDa): 19.285

UniProt ID(s): C0H4H1

PDB ID(s): None

Isoelectric Point: 10.49

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
15591203 A host-targeting signal in virulence proteins reveals a secretome in malarialinfection. Hiller NL, Bhattacharjee S, ..., Haldar K 10.1126/science.1102737
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g