PF3D7_0600400 (VAR)

Genome location: Pf3D7_06_v3:17,777..23,068(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: erythrocyte membrane protein 1, PfEMP1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.00	1.00
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.00	1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0600400

Resistome Missense Mutations: I187T

Resistome Compounds with Missense Mutations: AN13762, KAE678/NITD678

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 3 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.601 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6KSL0

"Best" AlphaFill ligand hit: 3PO (triphosphate, Local RMSD=0.27) with 5MZA (Global RMSD=5.12)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 1263

Non-coding: 298 | Synonymous: 386 | Nonsynonymous: 570 | Stop Codon: 9

Protein Information

Protein Length: 1325 | Molecular Weight (kDa): 153.299

UniProt ID(s): A0A5P1A085, A0A5P1A0I1, A0A5P1A0K5, A0A5P1A0L0, A0A5P1A0U5, A0A5P1A1J3, A0A5P1A277, A0A5P1A2A3, A3R6U7, C6KSL0, Q6UDW2, Q6UDW4, Q9U5M2

PDB ID(s): None

Isoelectric Point: 6.2

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008602	Duffy-antigen binding
InterPro	IPR029210	Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment
InterPro	IPR029211	Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment
PFam	PF05424	Duffy-antigen binding
PFam	PF15445	Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment
PFam	PF15447	Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment
Superfamily	SSF140924	N/A