PF3D7_0600600 (VAR)

Genome location: Pf3D7_06_v3:29,618..31,484(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: erythrocyte membrane protein 1 (PfEMP1), exon 2

SignalP Peptide: MMSISAFPLSVGIAFA

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	nd	1.00
Trophozoite	possibly expressed	0.00	1.00
Schizont	possibly expressed	0.00	1.00
Gametocyte	not expressed	0.00	1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0600600

Resistome Missense Mutations: P27T, P27S, K28Q, S29T, M100L

Resistome Compounds with Missense Mutations: AN13762, Desoxyepothilone B

Resistome # Samples with Disruptive Mutations: 4 (4 missense, 4 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.999 | MFS: -1.962 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 726

Non-coding: 167 | Synonymous: 343 | Nonsynonymous: 213 | Stop Codon: 3

Protein Information

Protein Length: 440 | Molecular Weight (kDa): 50.326

UniProt ID(s): A3R6U9, Q9XZB8

PDB ID(s): None

Isoelectric Point: 4.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR029211	Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment
PFam	PF15445	Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment
Superfamily	N/A	N/A